| 主权项 |
1. A compound having formula (I): including hydrates, solvates, enantiomers, diastereomers, pharmaceutically acceptable salts, prodrugs and complexes thereof, wherein: A1 is selected from the group consisting of nitrogen and CH; A2 is selected from the group consisting of nitrogen and CH; At least one of A1 and A2 is nitrogen; R1 is selected from the group consisting of hydrogen, fluorine, OR4, NR5aR5b, R2 is selected from the group consisting of hydrogen, fluorine, OR7, NR5aR5b, At least one of R1 and R2 is not hydrogen; R3a, R3b, R3c, R3d, and R3e are each independently selected from the group consisting of hydrogen, halogen, OH, optionally substituted C1-6 linear alkyl, optionally substituted C1-6 branched alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted C1-6haloalkyl, C1-6, optionally substituted alkoxy, —NR8aR8b, —NR9COR10, —CO2R10, —CONR8aR8b, —NHSO2R11, —SH, —SR11, SO2R11 and —SO2NHR10; R4 is an optionally branched C1-6 alkyl; R5a is an optionally branched C1-6 alkyl; R5b is an optionally branched C1-6 alkyl; R5a and R5b are taken together with the atoms to which they are bound to form an optionally substituted 5 membered ring; R5a and R5b are taken together with the atoms to which they are bound to form an optionally substituted 6 membered ring; R6 is selected from the group consisting of hydrogen, optionally branched C1-6 alkyl, optionally branched C3-6 cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, and COR11; R7 is an optionally branched C1-6 alkyl; R4 and R7 are taken together with the atoms to which they are bound to form an optionally substituted 5 membered ring; R4 and R7 are taken together with the atoms to which they are bound to form an optionally substituted 6 membered ring; R8a and R8b are each independently selected from the group consisting of hydrogen, optionally substituted C1-6 linear alkyl, optionally substituted C1-6 branched alkyl, and optionally substituted C3-7 cycloalkyl; R9 is selected from the group consisting of hydrogen, optionally substituted C1-6 linear alkyl, optionally substituted C1-6branched alkyl, and optionally substituted C3-7 cycloalkyl; R10 is selected from the group consisting of hydrogen, optionally substituted C1-6 linear alkyl, optionally substituted C1-6branched alkyl, and optionally substituted C3-7 cycloalkyl; R11 is selected from the group consisting of optionally substituted C1-6 linear alkyl, optionally substituted C1-6branched alkyl, and optionally substituted C3-7 cycloalkyl. |
