| 发明名称 |
Method for screening substance having proangiogenic effect |
| 摘要 |
It is intended to provide an angiogenic agent which contains, as the active ingredient, at least one substance selected from the group consisting of adrenomedullin, a substance inhibiting the activity of adrenomedullin degrading enzyme, an adrenomedullin receptor activity-modifying protein, a calcitonin receptor-like receptor and an adrenomedullin receptor. |
| 申请公布号 |
US9072777(B2) |
申请公布日期 |
2015.07.07 |
| 申请号 |
US200611922261 |
申请日期 |
2006.03.01 |
| 申请人 |
|
发明人 |
Shindo Takayuki |
| 分类号 |
C12Q1/02;A61K45/06;A61K38/18;A61K38/17;A61K38/22;A61K48/00 |
主分类号 |
C12Q1/02 |
| 代理机构 |
Hoffmann & Baron, LLP |
代理人 |
Hoffmann & Baron, LLP |
| 主权项 |
1. A method for screening a substance having an effect enhancing angiogenesis, comprising: administering a substance to a cell with reduced expression of endogenous RAMP 2 gene, wherein the substance is not adrenomedullin, measuring signal transduction within the cell, analyzing an effect of the substance on angiogenesis in the cell in vitro, and selecting the substance showing similar signal transduction to adrenomedullin by exhibiting enhanced angiogenesis. |
| 地址 |
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