发明名称 Method for producing n-substituted-2-amino-4-(hydroxymethylphosphinyl)-2-butenoic acid
摘要 <p>Provided is a method for producing a compound expressed by the following formula (3): [where R 1 represents a hydrogen atom or C 1-4 alkyl group, and R 2 represents C 1-4 alkyl group, C 1-4 alkoxy group, aryl group, aryloxy group or benzyloxy group], the method comprising a reaction of dehydro-condensing a compound expressed by the following formula (1): [where R 1 represents the same meaning as defined above], and a compound expressed by the following formula (2): [where R 2 represents the same meaning as defined above], while being converted to a desired geometric isomer in the presence or absence of an acid catalyst, under a condition that an organic solvent to be used for the reaction is a mixed solvent of acetic acid and a solvent selected from the group consisting of toluene, xylene and chlorobenzene, and a mixing ratio of acetic acid to the other solvent is from 1:3 to 1:5 in volume, wherein the reaction is conducted under heating and refluxing.</p>
申请公布号 IL223411(A) 申请公布日期 2015.06.30
申请号 IL20120223411 申请日期 2012.12.03
申请人 MEIJI SEIKA PHARMA CO. LTD.;TAKASHI ANDO;NOBUTO MINOWA;MASAAKI MITOMI 发明人 TAKASHI ANDO;NOBUTO MINOWA;MASAAKI MITOMI
分类号 C07B;C07F 主分类号 C07B
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