Facile Method for Making Non-Toxic Biomedical Compositions Comprising Hybrid Metal-Polymer Microparticles

摘要

The present invention includes photochemical method of making hybrid metal-polymer microparticles in an aqueous, biocompatible solution by providing a metal (I) composition and one or more polymeric materials; applying an electromagnetic radiation to the metal (I) composition; converting the metal (I) composition to a metal (0) composition; forming one or more hybrid metal-polymer microparticles from the metal (0); capping the or more hybrid metal-polymer microparticles; and stabilizing the one or more hybrid metal-polymer microparticles with the one or more polymeric materials to prevent agglomeration.

主权项

1. A method of making a plasmonic hybrid metal-polymer microparticle agent complex comprising the steps of:
forming a hybrid metal-polymer microparticle with a tunable NIR plasmon absorption in an aqueous, biocompatible solution by
providing an aqueous biocompatible solution;combining a metal (I) composition and one or more polymeric materials in the aqueous biocompatible solution;applying an electromagnetic radiation, a thermal energy, a mechanical energy, sonication energy or a combination thereof to the metal (I) composition to convert the metal (I) composition to a metal (0) composition;forming one or more hybrid metal-polymer microparticles from the metal (0);capping the one or more hybrid metal-polymer microparticles; and stabilizing the one or more hybrid metal-polymer microparticles with the one or more polymeric materials to prevent agglomeration and provide the NIR plasmon absorption of the one or more hybrid metal-polymer microparticles between 700 nm-1200 nm; and forming one or more stabilized hybrid metal-polymer microparticles.