| 发明名称 |
METHOD FOR DETERMINING DISEASE SEVERITY IN TAUOPATHY-RELATED NEURODEGENERATIVE DISORDERS |
| 摘要 |
A method for determining disease severity in a subject afflicted with a tauopathy-related neurodegenerative disease comprises detecting the level of a PINCH protein or isoform thereof in a test sample comprising brain tissue or cerebrospinal fluid. The PINCH protein level in the test sample indicates the relative severity of the tauopathy-related neurodegenerative disease afflicting the subject. |
| 申请公布号 |
US2015147766(A1) |
申请公布日期 |
2015.05.28 |
| 申请号 |
US201314403876 |
申请日期 |
2013.05.23 |
| 申请人 |
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
Langford Teresa Dianne;Merali Salim |
| 分类号 |
G01N33/68;C12Q1/37 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for determining disease severity in a subject afflicted with a tauopathy-related neurodegenerative disease comprising:
detecting the level of a PINCH protein in a test sample comprising brain tissue or cerebrospinal fluid from a subject afflicted with a tauopathy-related neurodegenerative disease; comparing said level of said PINCH protein in said test sample with the level of said PINCH protein in at least one control sample; wherein the level of said PINCH protein in the test sample as compared to the level in the control sample indicates the relative severity of the tauopathy-related neurodegenerative disease afflicting the subject. |
| 地址 |
PHILADELPHIA PA US |
