METHODS OF DETECTING DISEASES OR CONDITIONS USING CIRCULATING DISEASED CELLS

摘要

This invention provides methods of using circulating diseased cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using circulating diseased cells to identify markers of diseases or conditions. This invention also provides methods for assessing the risk of developing a disease or condition, prognosing said disease, monitoring said disease progression or regression, assessing the efficacy of a treatment, or identifying a compound capable of ameliorating or treating said disease or condition.

主权项

1. A method for diagnosing or aiding in the diagnosis of a disease or condition in a subject comprising:
a) determining a first profile of one or more markers of the disease or condition from a population of circulating diseased cells isolated from the subject, wherein the circulating diseased cells are affected by the disease or condition; b) determining a second profile of at least one of the one or more markers from a population of control cells or a control bodily fluid sample isolated from the subject, wherein the control cells or the control bodily fluid sample are substantially free of cells affected by the disease or condition; and c) identifying a difference between the first and second profiles, wherein the difference is indicative of the presence of said disease or condition in the subject.