| 摘要 |
A cosmetic composition including as an active substance a cosmetically effective amount of at least one mu-conotoxin peptide It further concerns a composition wherein the mu-conotoxin peptide is Argninine, lysine polypeptide, CAS Number: 937286-43-6, Molecular formula C92, H139, N35, O28, S6 acetate salt (molar mass 2376 g/mol.). Also, the use of the composition to improve the mechanical properties of the skin, tonicity and/or firmness and/or elasticity of the skin. |
| 主权项 |
1. A cosmetic composition comprising as an active substance a cosmetically effective amount of at least one mu-conotoxin peptide comprising the amino acid sequence:
Xaa1-Xaa2-Cys-Cys-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Cys-Xaa8-Xaa9-Xaa10-Xaa11-Cys-Xaa12-Xaa13-Xaa14-Xaa15-Xaa16-Cys-Cys-Xaa17 [SEQ ID No 1] a biologically active fragment thereof, a salt thereof, a combination thereof and/or variants thereof, and wherein Xaa1 is any N-modified amino acid, Xaa2 is glycine, Xaa3 is any acidic amino acid or any of its amide form, Xaa4 is glycine, Xaa5 is proline or hydroxy-proline, Xaa6 is any basic amino acid, Xaa7 is glycine, Xaa8 is any non-aromatic hydroxyl amino acid, Xaa9 is any non-aromatic hydroxyl amino acid, Xaa10 is any basic amino acid, Xaa11 is any aromatic amino acid, Xaa12 is any basic amino acid, Xaa13 is any acidic amino acid or any of its amide form, Xaa14 is any basic amino acid, or any sulfur-containing amino acid, Xaa15 is any hydrophobic or apolar amino acid, or any non-aromatic hydroxyl amino acid, Xaa16 is any basic amino acid, Xaa17 is absent or is any apolar amino acid, or an amide group, optionally in combination with cosmetic acceptable carriers, diluents and/or adjuvants. |
