| 发明名称 |
MICRO-ORGANS PROVIDING SUSTAINED DELIVERY OF A THERAPEUTIC POLYPEPTIDE AND METHODS OF USE THEREOF |
| 摘要 |
The present invention is directed to long-lasting therapeutic formulations and their methods of use wherein the formulation comprises a genetically modified micro-organ that comprises a nucleic acid sequence operably linked to one or more regulatory sequences. The present invention is further directed to methods providing sustained expression of therapeutic polypeptides and prolonged therapeutic effects, such as erythropoietin and interferon. |
| 申请公布号 |
US2015118187(A1) |
申请公布日期 |
2015.04.30 |
| 申请号 |
US201414520831 |
申请日期 |
2014.10.22 |
| 申请人 |
MEDGENICS MEDICAL ISRAEL LTD. |
发明人 |
Shapir Nir;Miari Reem;Stern Baruch S.;Blum Shany;Rimler Avi |
| 分类号 |
A61K38/18;C07K14/505;C12N5/071;A61K31/573;A61K35/36;C12N15/86;C07K14/56 |
主分类号 |
A61K38/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A genetically modified micro-organ that provides a sustained delivery of a therapeutic polypeptide, said micro-organ comprising a vector comprising a nucleic acid sequence encoding said therapeutic polypeptide operably linked to an upstream MAR regulatory sequence and comprising at least one additional regulatory sequence, wherein said at least one genetically modified micro-organ expresses said therapeutic polypeptide for a sustained period of at least three months in a subject in vivo. |
| 地址 |
Misgav IL |
