SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES

摘要

This invention relates to novel substituted triazolo-pyridazines, their derivatives, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an α1-GABA-A receptor antagonist and/or a α2, α3 and α5 GABA-A receptor agonist.

主权项

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:
R1 is CH3, CDH2, CD2H, or CD3; R2 is a t-butyl group having 0-9 deuterium atoms; each Y is independently hydrogen or deuterium; and when R1 is CH3 and each Y is hydrogen, then R2 has 1-9 deuterium.