Rapid detection and identification of energetic materials with surface enhanced raman spectrometry (SERS)

摘要

In one embodiment, a system includes a plurality of metal nanoparticles functionalized with a plurality of organic molecules tethered thereto, wherein the plurality of organic molecules preferentially interact with one or more analytes when placed in proximity therewith. According to another embodiment, a method for detecting analytes includes contacting a fluid having one or more analytes of interest therein with a plurality of metal nanoparticles, each metal nanoparticle having a plurality of organic molecules tethered thereto, and detecting Raman scattering from an analyte of interest from the fluid, the analyte interacting with one or more of the plurality of organic molecules. In another embodiment, a method includes chemically modifying a plurality of cyclodextrin molecules at a primary hydroxyl moiety to create a chemical handle, and tethering the plurality of cyclodextrin molecules to a metal nanoparticle using the chemical handle. Other systems and methods for detecting analytes are also described.

主权项

1. A system, comprising:
one or more analytes; and a plurality of metal nanoparticles functionalized with a plurality of organic molecules tethered thereto, each organic molecule having a primary face and a secondary face, wherein the plurality of organic molecules preferentially interact with the one or more analytes when placed in proximity therewith, wherein the plurality of organic molecules comprise one or more of:
one or more modifying groups on the primary face in place of one or more primary hydroxyl groups; andone or more modifying groups on the secondary face in place of one or more secondary hydroxyl groups, wherein at least one of the one or more analytes is an energetic compound selected from a group consisting of: trinitrotoluene (TNT), tetrahexamine tetranitramine (HMX), cyclotrimethylenetrinitramine (RDX), pentaerythritol tetranitrate (PETN), 2,4,6-trinitrophenylmethylnitramine (Tetryl), and peroxides.