| 发明名称 |
REPEBODY FOR NOVEL INTERLEUKIN-6 AND USE THEREOF |
| 摘要 |
The present invention relates to an repebody capable of binding specifically to interleukin-6 (IL-6) to inhibit the biological activity of IL-6, a polynucleotide encoding the repebody, a vector comprising the polynucleotide, a recombinant microorganism having introduced therein the polynucleotide or the vector, a method of producing the repebody using the recombinant microorganism, a composition for preventing or treating cancer, which comprises the repebody, and a method for preventing or treating cancer, which comprises administering the composition for preventing or treating cancer, which comprises the repebody. The repebody of the present invention significantly reduces the activity of STAT3 and the concentration of interleukin-6, and thus can be widely used as an agent for preventing or treating IL-6-related diseases. |
| 申请公布号 |
US2015094450(A1) |
申请公布日期 |
2015.04.02 |
| 申请号 |
US201314381407 |
申请日期 |
2013.02.27 |
| 申请人 |
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ;THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) ;KOREA BASIC SCIENCE INSTITUTE |
发明人 |
Kim Hak-Sung;Lee Joong-Jae;Choi Jung Min;Jo Eun-Kyeong;Yang Chul-Su;Cheong Hae-Kap;Kim Hyun Jung |
| 分类号 |
C07K16/24;C07K14/705;C07K14/195 |
主分类号 |
C07K16/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A repebody binding to interleukin-6 (IL-6) comprising a structure in which the N-terminal of leucine-rich repeat (LRR) family protein having an alpha-helix capping motif, which is of microbial origin, modified repeat module of variable lymphocyte receptor (VLR) protein, and C-terminal of the VLR protein are fused. |
| 地址 |
Daejeon KR |
