发明名称 |
2',5'-DIDEOXY-5-FLUOROURIDINE DERIVATIVES HAVING CYTOTOXIC ACTIVITY, A PROCESS FOR THE MANUFACTURE THEREOF AND APPLICATION THEREOF |
摘要 |
The subject matter of the invention is novel 2',5'-dideoxy-5-fluorouridine derivatives of general formula 1. (1) wherein R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8and C-9 atoms. In a second aspect, the subject matter of the invention is a process for the manufacture of 2',5'- dideoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2',5'-dideoxy-5- fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer. |
申请公布号 |
WO2015041550(A1) |
申请公布日期 |
2015.03.26 |
申请号 |
WO2014PL50010 |
申请日期 |
2014.03.04 |
申请人 |
ADAM MICKIEWICZ UNIVERSITY;CELEWICZ, LECH;KACPRZAK, KAROL;LEWANDOWSKA, MARTA;RUSZKOWSKI, PIOTR;KLECZEWSKA, NATALIA |
发明人 |
CELEWICZ, LECH;KACPRZAK, KAROL;LEWANDOWSKA, MARTA;RUSZKOWSKI, PIOTR;KLECZEWSKA, NATALIA |
分类号 |
C07H19/06;A61K31/7072;A61P35/00 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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