METHODS AND COMPOSITIONS FOR TUMOR VASCULATURE IMAGING AND TARGETED THERAPY

摘要

Provided are compositions and methods for imaging one or more of tumor vasculature and tumor angiogenesis, wherein an imaging composition comprises anti-SFRP2 antibody operable linked to an imaging agent. Provided is a method of imaging tumor vasculature in an individual comprising administering to the individual a diagnostically effect of an imaging composition, and detecting the image resulting from the binding or complexing of the imaging composition with tumor vasculature. The imaging agent may also be used as a delivery vehicle to target one or more therapeutic agents to tumor vasculature and surrounding tumor tissue.