| 摘要 |
<p>The invention relates to a coating agent for the gastric juice-resistant coating of capsule halves, which are made of a water-soluble or water-swellable polymer material, in a dip coating process, in the form of an aqueous dispersion or solution, containing a polymer mixture of at least an initial (meth)acrylate copolymer that is gastric juice-resistant, as well as auxiliary materials that influence the viscosity of the dispersion and the elasticity of the dried polymer film, characterized in that the solids content of the dispersion or solution is more than 25 percent by weight and the viscosity is 150 to 1,500 mPas, wherein a film generated by the dispersion or solution and dried has an ultimate elongation of at least 200 percent and a capsule composed of two capsule halves coated with the dispersion or solution in the dip coating process does not dissolve in 0.1 N HCl at a pH of 1.2 after two hours, but does completely dissolve subsequently in a buffer at a pH of 6.8 in less than 30 minutes.</p> |
