| 摘要 |
<p>The present invention provides a novel fused bicyclic compound having an affinity to a receptor of mineral corticoid (MR), shown by the formula [I]:
wherein the ring A is a benzene ring having a substituent R 1 , fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R 1 ,
R 1 is an alkylsulfonylamino group etc.,
R 2 and R 3 are (a) the same of different and a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, (b) combined each other to form an oxo group or (c) combined each other at its terminal together with the adjacent carbon atom to form a cycloalkyl group,
X is a group of =N-, =C(R 4 )- or -CH(R 4 )-,
R 4 is (a) a hydrogen atom, (b) a cyano group, (c) a halogen atom, (d) an alkyl group, (e) an alkenyl group, (f) a cycloalkyl group (g) an alkanoyl group, (h) a carbamoyl group or (i) a cycloalkenyl group,
Ar is an optionally substituted aromatic cyclic group and
a dotted line means presence or absence of a double bond,
or a pharmaceutically acceptable salt thereof,
which is useful as an antihypertensive agent etc.</p> |
