Use of inhaled xenon for preventing or treating neuropathic pain induced by platinum salts

摘要

#CMT# #/CMT# Gaseous inhalable medicament containing xenon or nitrous oxide as active ingredient for preventing and/or treating neuropathic pain, where the neuropathic pain is induced by at least one cancer chemotherapy substance administered to a patient suffering from cancer, and the cancer chemotherapy substance comprises one or more compounds of platinum salts, taxanes, alkaloids, thalidomide and bortezomib. #CMT#ACTIVITY : #/CMT# Analgesic. #CMT#MECHANISM OF ACTION : #/CMT# None given. #CMT#USE : #/CMT# The medicament is useful for preventing and/or treating neuropathic pain induced by at least one cancer chemotherapy substance administered to a patient suffering from cancer, preferably the patient suffering from breast cancer, lung cancer, ovarian cancer, prostate cancer, colon cancer, rectal cancer or a gastric cancer or cancer of the upper aerodigestive tracts, where the patient is a human being (all claimed). Tests details are described but no results given. #CMT#PHARMACEUTICALS : #/CMT# Preferred Composition: The medicament further comprises at least 21 vol.% of oxygen, and an additional gas comprising argon, helium, neon, krypton, nitric oxide, carbon monoxide, hydrogen sulfide or nitrogen. The medicament is coadministered with the cancer chemotherapy substance. Preferred Components: The platinum salts comprise cisplatin, oxaliplatin (preferred) or carboplatin. The taxane comprises paclitaxel or docetaxel. The amount of nitrous oxide or xenon is 5-70 vol.%, preferably less than 30 vol.%. #CMT#ADMINISTRATION : #/CMT# Administration of the medicament is by inhalation for at least 15 minutes per day, preferably less than 30 minutes per day (claimed). No dosage details given. #CMT#EXAMPLE : #/CMT# No suitable example given.