发明名称 |
MODIFIED OLIGONUCLEOTIDES COMPRISING THIOL FUNCTIONS AND THE USE OF SAME FOR THE DETECTION OF NUCLEIC ACIDS |
摘要 |
The present invention relates to a modified oligonucleotide having two or more thiol functions, which can be immobilized on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or carbon-carbon triple bond or haloacetamide functions, preferably maleimide or acrylamide functions. The invention also relates to a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridization between a modified oligonucleotide and a target nucleic acid amplified from the biological sample. The invention relates more particularly to a method for detecting, genotyping or sequencing a pathogenic organism, preferably a virus. |
申请公布号 |
KR20150021493(A) |
申请公布日期 |
2015.03.02 |
申请号 |
KR20147027987 |
申请日期 |
2013.04.04 |
申请人 |
ETABLISSEMENT FRAN&CCEDIL,AIS DU SANG;UNIVERSITE DE MONTPELLIER 1;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS);UNIVERSITE CLAUDE BERNARD LYON I |
发明人 |
FOURNIER WIRTH CHANTAL;LEREAU MYRIAM;CANTALOUBE JEAN FRANCOIS;VASSEUR JEAN JACQUES;MORVAN FRANCOIS;MEYER ALBERT;MAYEN JULIE;CHAIX CAROLE;FARRE CAROLE |
分类号 |
C12Q1/70;C07H21/00;C12Q1/68 |
主分类号 |
C12Q1/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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