| 摘要 |
The present invention relates to pyrazolo-quinazolines, characterized by an ortho-substituted arylamino-, heterocyclylamino- or C-Ccycloalkylamino residue at 8 position and an aryl, heterocyclyl or C-Ccycloalkyl as substituent of a carboxamide at 3 position of the molecula framework. The compounds of this invention modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular MPS1/TTK. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. |
