gadolinium complexs for contrast agent and contrast agent for diagnosing hepatoma

摘要

PURPOSE: A gadolinium complex for a contrast agent for diagnosing liver cancer is provided to effectively deliver gadolinium to a liver cell and to improve contrasting ability. CONSTITUTION: A gadolinium complex for a contrast agent for diagnosing liver cancer contains gadolinium(Gd) which is conjugated to a DTPA-HA intermediate material which is formed by reaction of DTPA(diethylene triamine pentaacetic acid) with HA(hyaluronic acid). The DTPA-HA intermediate is denoted by chemical formula 1. A method for preparing the gadolinium complex comprises: a step of reacting DTPA(diethylene triamine pentaacetic acid) with hyaluronic acid(HA) in an organic solvent and generating the DTPA-HA intermediate; and a step of binding gadolinium to the DTPA-HA intermediate. A contrast agent for diagnosing liver cancer contains the gadolinium complex.