| 摘要 |
<p>L-Cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and has been modified so that the activity of a protein encoded by a tolC gene, for example, a protein defined in the following (A) or (B) is increased, in a medium and collecting L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof from the medium:
(A) a protein comprising the amino acid sequence of SEQ ID NO: 2,
(B) a protein comprising the amino acid sequence of SEQ ID NO: 2 including substitutions, deletions, insertions or additions of one or several amino acid residues, increase of which activity in the bacterium improves L-cysteine-producing ability of the bacterium.</p> |
