发明名称 |
QUINIC ACID DERIVATIVE, PROCESS FOR PREPARATION AND USES THEREOF |
摘要 |
The present invention relates to a quinic acid derivative, preparation process of the same and pharmaceutical uses thereof. The quinic acid derivative has a quinic acid-like structure which binds to CD28, blocks T-cell signal 2 pathway via CD28, and suppresses T-cell activation. The C-1 carboxyl group, the C-3 hydroxyl group and the C-4 hydroxyl group of quinic acid are modified to attenuate the cytotoxicity of the quinic acid derivative. The preparation process of the quinic acid derivative comprises 2 steps of: treating quinic acid with the first reagent in the presence of the acid catalyst to form an immediate; and treating the immediate with the second reagent to from the quinic acid derivative. With the ability to suppress T-cell activation, the quinic acid derivative is used to treats an autoimmune disease, an allergy, transplant rejection or other related immune disorder. |
申请公布号 |
US2014371445(A1) |
申请公布日期 |
2014.12.18 |
申请号 |
US201313916665 |
申请日期 |
2013.06.13 |
申请人 |
NATIONAL APPLIED RESEARCH LABORATORIES |
发明人 |
CHEN HUEIH-MIN;SUN CHUNG-MING;HUANG CHIH-YU |
分类号 |
C07D317/72 |
主分类号 |
C07D317/72 |
代理机构 |
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代理人 |
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主权项 |
1. A quinic acid derivative, comprising a quinic acid-like structure for binding to CD28. |
地址 |
Taipei City TW |