3-SULFONYL-PYRAZOLO[1,5-A]PYRIMIDINER/ANTAGONISTER AF SEROTONIN 5-HT6-RECEPTORER, FREMGANGSMÅDER TIL FREMSTILLINGEN OG ANVENDELSEN DERAF

摘要

The present invention relates to novel substituted 3-(arylsulfonyl)pyrazolo[1,5-a]pyrimidines of general formula 1 pharmaceutically acceptable salts and/or hydrates, to novel serotonin 5-HT 6 receptor antagonists, to novel drug substances, pharmaceutical compositions, medicaments and methods for their preparation and use for treatment and prophylaxis of pathological states and diseases of CNS, pathogenesis of which is associated with disturbance of serotonin 5-HT 6 receptor activation. In compounds of general formula 1
Ar represents optionally substituted aryl or heterocyclyl; R 1 , R 2 and R 3 independently of each other represent hydrogen, C 1 -C 3 alkyl or phenyl; R 4 represents hydrogen, optionally substituted C 1 -C 5 alkyl, substituted hydroxyl group or substituted sulfanyl group.