Methods of treatment with biodegradation of a stent scaffolding

摘要

Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.

主权项

1. A method of treating stenosis in a blood vessel of a patient comprising:
providing a bioabsorbable stent including a cylindrically-shaped scaffolding and a coating on an inner side and an outer side of the scaffolding, wherein the scaffolding includes a first bioabsorbable polymer including poly(L-lactide) and the coating includes a second bioabsorbable polymer and a drug, wherein the scaffolding is composed of a pattern of interconnected struts formed by laser cutting the pattern into a tube, wherein the stent is mounted over a balloon in a crimped state that is compressed from a cut state, introducing the mounted stent into a blood vessel of a patient in need of treatment for atherosclerotic stenosis; transporting the mounted stent to a site of stenosis in the blood vessel; and expanding and implanting the mounted stent at the site of stenosis by inflating the balloon which expands the site of stenosis in the blood vessel, wherein the implanted stent delivers the drug to the wall of the blood vessel, maintains patency of the blood vessel at the site for a period of time, becomes endothelialized within a wall of the blood vessel, and is made to completely disappear by degradation or degrade with negligible traces of polymer or residue left behind.