Novel insulin derivatives

摘要

The present invention relates to insulin derivatives which are naturally occuring insulins or analogues thereof which have a side chain attached either to the a-amino group of the N-terminal amino acid residue of the B chain or to the e-amino group of a Lys 5 residue present in the B chain of the parent insulin, the side chain being of the general formula: -W-X-Y-Z wherein W, X, Y and Z are as defined in the disclosure.