发明名称 |
IMPROVED GLYCAN ARRAYS AND METHODS FOR THEIR FABRICATION |
摘要 |
The invention relates to glycan arrays with quantified levels of glycan expression and a method for fabricating thereof. The method comprises quantitatively reacting an omega-aminoalkylglycan with an activated polymer of an acrylic acid derivative to obtain glycoconjugated polymer or copolymer and covalently attaching the (co)polymer to a functionalized substrate. The glycan arrays according to the invention comprise an co-aminoalkylglycan covalently attached to a functionalized substrate via a fluorescently labeled (co)polymer of an acrylic acid derivative. The copolymer of an acrylic acid derivative may comprise fluorescein cadaverine as a fluorescent label or lysine or aminated PEG. The functionalized substrate is selected from an epoxylated and aminated glass or plastic. The invention also provides a fluorescently labeled co-aminoalkylglycan conjugated polymer of an acrylic acid derivative for use in the fabrication of glycan arrays. |
申请公布号 |
EP2686022(A4) |
申请公布日期 |
2014.10.15 |
申请号 |
EP20100861250 |
申请日期 |
2010.12.30 |
申请人 |
OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU "SEMIOTIK" |
发明人 |
BOVIN, NIKOLAY VLADIMIROVICH;SHILOVA, NADEZHDA VLADIMIROVNA |
分类号 |
A61K49/06;C07H7/06;G01N33/533;G01N33/543 |
主分类号 |
A61K49/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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