pH-sensitive microparticles with matrix-dispersed active agent

摘要

Methods to produce pH-sensitive microparticles that have an active agent dispersed in a polymer matrix have certain advantages over microcapsules with an active agent encapsulated in an interior compartment/core inside of a polymer wall. The current invention relates to pH-sensitive microparticles that have a corrosion-detecting or corrosion-inhibiting active agent or active agents dispersed within a polymer matrix of the microparticles. The pH-sensitive microparticles can be used in various coating compositions on metal objects for corrosion detecting and/or inhibiting.

主权项

1. A method of forming microparticles comprising:
dissolving or dispersing a prepolymer in a solvent A; mixing an active agent or active agents dispersed or dissolved in a solvent B with the prepolymer in solution or dispersion in solvent A; and polycondensing the prepolymer to form a polymer matrix and to form microparticles comprising the active agent or active agents dispersed in the polymer matrix; wherein the polymer backbone or a cross-linking segment of the polymer matrix is susceptible to hydrolysis in base; wherein solvents A and B are the same or different solvents; wherein solvents A and B are miscible with each other.