发明名称 |
Size-based analysis of fetal DNA fraction in maternal plasma |
摘要 |
<p>A fractional concentration of clinically-relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments at multiple sizes. For example, the fractional concentration of fetal DNA in maternal plasma or tumor DNA in a patient's plasma can be determined. The size of DNA fragments in a sample is shown to be correlated with a proportion of fetal DNA and a proportion of tumor DNA, respectively. Calibration data points (e.g., as a calibration function) indicate a correspondence between values of a size parameter and the fractional concentration of the clinically-relevant DNA. For a given sample, a first value of a size parameter can be determined from the sizes of DNA fragments in a sample. A comparison of the first value to the calibration data points can provide the estimate of the fractional concentration of the clinically-relevant DNA.</p> |
申请公布号 |
AU2013229186(A1) |
申请公布日期 |
2014.09.18 |
申请号 |
AU20130229186 |
申请日期 |
2013.03.08 |
申请人 |
THE CHINESE UNIVERSITY OF HONG KONG |
发明人 |
LO, YUK MING DENNIS;CHAN, KWAN CHEE;ZHENG, WENLI;JIANG, PEIYONG;LIAO, JIAWEI;CHIU, WAI KWUN ROSSA |
分类号 |
C12Q1/68;G06F19/18;G06F19/20 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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