| 主权项 |
1. A method for the treatment of an impairment of learning and/or memory in a human or animal which comprises administering to the human or animal an amount effective for such treatment of a compound of the formula (I): in which R1 is C1-C8-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C3-C8-cycloalkyl, where C1- C8-alkyl is optionally substituted by oxo, and
where C1-C8-alkyl, C2-C6-alkenyl, C2-C6-alkynyl and C3-C8-cycloalkyl are optionally substituted by up to 3 radicals independently of one another selected from the group of C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, cyano, amino, nitro, hydroxy, C1-C6-alkylamino, halogen, trifluoromethyl, trifluoromethoxy,C6-C10-arylcarbonylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylamino-carbonyl, C1-C6-alkoxycarbonyl, C6-C10-arylaminocarbonyl, heteroarylamino-carbonyl, heteroarylcarbonylamino, C1-C6-alkylsulphonylamino, C1-C6-alkylsulphonyl,C1-C6-alkylthio,whereC1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino, C6-C10-arylcarbonylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl, C1-C6-alkoxy-carbonyl,
C6-C10-arylaminocarbonyl, heteroarylaminocarbonyl, heteroarylcarbonylamino, C1-C6-alkylsulphonylamino, C1-C6-alkyl-sulphony and C1-C6-alkylthio are optionally substituted by one to three radicals independently of one another selected from the group of hydroxy, cyano, halogen, trifluoromethyl, trifluoromethoxy, hydroxy-carbonyl and a group of the formula —NR3R4,whereR3 and R4 are independently of one another hydrogen or C1-C6-alkyl,orR3 and R4 together with the nitrogen atom to which they are bonded are 5- to 8-membered heterocyclyl, R2 is phenyl or heteroaryl, where phenyl is substituted by 1 to 3 radicals and heteroaryl is optionally substituted by 1 to 3 radicals in each case independently of one another selected from the group of C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, cyano, trifluoromethyl, trifluoromethoxy, amino, nitro, hydroxy, C1-C6-alkylamino, halogen, C6-C10-arylcarbonylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl, C1-C6-alkoxycarbonyl, C6-C10-arylaminocarbonyl, heteroarylaminocarbonyl, heteroarylcarbonylamino, C1-C6-alkylsulphonyl amino, C1-C6-alkylsulphonyl and C1-C6-alkylthio,
where C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino, C6-C10-arylcarbonyl-amino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl, C 1-C6-alkoxycarbonyl, C6-C10-arylaminocarbonyl, heteroarylaminocarbonyl, heteroarylcarbonylamino, C1-C6-alkylsulphonylamino, C1-C6-alkylsulphonyl and C1-C6-alkylthio are optionally substituted by one to three radicals independently of one another selected from the group of hydroxy, cyano, halogen, trifluoromethyl, trifluoromethoxy, hydroxycarbonyl and a group of the formula —NR3R4,
whereR3 and R4 have the meanings indicated above, or a salt, solvate or solvate of a salt thereof. |
