| 主权项 |
1. A method of treating or preventing a metalloenzyme-mediated disease or disorder in or on a plant comprising contacting a compound of Formula I with the plant or seeds: wherein MBG is optionally substituted tetrazolyl, optionally substituted oxazolyl, optionally substituted pyrimidinyl, optionally substituted thiazolyl, or optionally substituted pyrazolyl; R1 is halo or haloalkyl; R2 is H, halo, alkyl, or haloalkyl; R3 is independently H, alkyl, alkenyl, cycloalkyl, heteroaryl, hydroxyalkyl, cyano, haloalkyl, halo, —C(O)phenyl, —CH(OH)(aryl), —CH2(aryl), —CH2(heteroaryl), —CF2(aryl), —CF2(heteroaryl), —CH2O(aryl), —CH2O(heteroaryl), —CH2S(O)x(aryl), and cyclic amino, wherein each of the alkyl, alkenyl, cycloalkyl, heteroaryl, hydroxyalkyl, haloalkyl, —C(O)phenyl, —CH(OH)(aryl), —CH2(aryl), —CH2(heteroaryl), —CF2(aryl), CF2(heteroaryl), —CH2O(aryl), —CH2O(heteroaryl), —CH2S(O)x(aryl), and cyclic amino may be optionally substituted with 1, 2 or 3 independent R7; R4 is aryl, heteroaryl, or cycloalkyl, each optionally substituted with 0, 1, 2 or 3 independent R8; R5 is independently H, halo, alkyl, alkoxy, cyano, haloalkyl, haloalkoxy, halothioalkyl, thioalkyl, SF3, SF6, SCN, SO2R11, cycloalkyl, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl; R6 is independently H, halo, alkyl, alkoxy, cyano, haloalkyl, haloalkoxy, halothioalkyl, thioalkyl, SF3, SF6, SCN, SO2R11, cycloalkyl, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl; each R7 is independently cyano, cycloalkyl, haloalkyl, hydroxy, alkoxy, aryl, aryloxy, heteroaryloxy, halo, haloalkoxy, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl; each R8 is independently cyano, haloalkyl, hydroxy, alkoxy, halo, or haloalkoxy; R9 is H, halo, or haloalkyl; R10 is H, alkyl, —Si(R12)3, —P(O)(OH)2, —CH2—O—P(O)(OH)2, or —C(O)alkyl optionally substituted with amino; R11 is independently alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; R12 is independently alkyl or aryl; and x is independently 0, 1, or 2. |
