Stable antiseptic compositions and methods

摘要

Provided are methods of improving the stability of antiseptic compositions that include elemental iodine and certain hydroxycarboxylic acids, as well as stable, ready to use antiseptic compositions suitable for use in the nose and anterior nares.

主权项

1. A tissue antiseptic composition comprising:
an antimicrobial agent which is an iodophor, wherein the iodophor is povidone-iodine, wherein the antimicrobial agent is present in a sufficient concentration to provide an available iodine concentration of 0.1 wt-% to 2 wt-%; a hydroxycarboxylic acid present at a concentration of at least 2.5 wt-%; an amine oxide; and an iodide salt present in at least a concentration of 2.0 wt-% and at an amount of no greater than 10 wt-%, wherein the composition is ready to use, and wherein the composition exhibits a decrease in available iodine of no greater than 5% wt/wt when stored at 40° C. for about 6 months.