Nucleic acids molecule encoding the polypeptide for treating virus-induced cancer

摘要

The present invention relates to nucleic acid molecules encoding the polypeptides that are capable of killing tumor cells. The molecules comprise a targeting agent covalently attached to a channel-forming moiety. In a preferred embodiment, the channel-forming moiety comprises a colicin and the targeting agent is a reconstructed antibody mimetic derived from monoclone antibody against Epstein-Barr virus gp350/220.

主权项

1. A nucleic acid molecule encoding a fusion polypeptide for treating a cell proliferative disorder in a mammal, the fusion polypeptide comprising:
a cancer cell targeting agent that targets mammalian cancer cells covalently attached to a channel-forming moiety, wherein said channel-forming moiety is a colicin selected from the group consisting of E1, Ia, Ib, A, K or N.