HAPTENS OF QUETIAPINE

摘要

The invention relates to compounds of Formula I, wherein R1, R2, and R3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.;

主权项

1. The compound of Formula I wherein: R1 is H,CH2NH2, or CH2NHC(O)(CH2)mCO2H, or Z—(Y)p-G;
R2 is H,CH2NH2, or CH2NHC(O)(CH2)mCO2H, or, Z—(Y)p-G;
R3 is H, or W—(Y)p-G; provided that two of R1, R2, R3 must be H, and further provided that R1, R2 and R3 may not all be H simultaneously; wherein: Z is selected from the group consisting of: —N(R4)—, —O—, —S—, -alkyl-, -aminoalkyl-, -thioalkyl-, -heteroalkyl-, -alkylcarbonyl-, R4 is H, an alkyl group, cycloalkyl group, aralkyl group or substituted or unsubstituted aryl group; wherein: W is selected from the group consisting of: —C(O)—, alkyl-, -aminoalkyl-, -thioalkyl-, -heteroalkyl-, -alkylcarbonyl-; Y is an organic spacer group; G is a functional linking group capable of binding to a carrier; p is 0, or 1; m is 1, 2, 3, 4, or 5; n is 1, 2, 3, 4, or 5.