| 主权项 |
1. A peptidic compound having a length of up to 35 amino acid residues comprising an amino acid sequence represented by the general formula (Ib):Z-[K]n-K-I-R-V-R-L-S-A(SEQ ID NO: 26) wherein K is a lysine or another amino acid residue with a positively charged side chain, I is an isoleucine, R is an arginine or an amino acid residue with an N-alkyl substituted guanidine side chain, V is a valine, S is a serine, A is an alanine, L is a leucine, wherein one of the amino acid residues K, I, R, L, V and S may be replaced by an alanine, Z is the N-terminal group of the peptidic compound which comprises at least one amino acid residue and is selected from (i) an aromatic amino acid residue or a di-, tri- or tetrapeptidyl group comprising at least one aromatic amino acid residue, wherein the aromatic amino acid residue is particularly selected from tryptophane, N-methyltryptophane, phenylalanine, β-phenylalanine, naphthylalanine, β-naphthylalanine, β-diphenylalanine,β-(4,4′-biphenyl)alanine, β-anthracen-9-ylalanine and β-indol-3-ylalanine, (ii) a branched aliphatic amino acid residue or a di-, tri-, tetrapeptidyl group comprising at least one aliphatic amino acid residue, wherein the aliphatic residue is α-amino acid residue comprising a branched aliphatic side chain of at least 3 C-atoms, (iii) combinations of any one of (i)-(ii), and n is 0 or 1, and wherein the peptidic compound comprises L- and/or D-amino acid residue building blocks, which are selected from α-amino carboxylic acids, β-amino carboxylic acids, or ω-amino carboxylic acids. |
