TGF-β signal transduction inhibitor

摘要

The present invention provides a compound represented by the following formula (I) or a physiologically acceptable salt thereof, and use thereof for the prophylaxis or treatment of TGF-β-related diseases:;whereinY is a hydrogen atom and the like;R2 is;and the like;R3 is —NR8—R9— and the like;R4, R5, R6 and R7 are the same or different and each is a hydrogen atom and the like; andX is;and the like.

主权项

1. A compound represented by the following formula (I): wherein Y is a hydrogen atom, a carboxyl group or wherein L is an oxygen atom or a bond, and R1 is optionally substituted C1-6 alkyl; R2 is R3 is —NR8—R9— or a bond, wherein R8 is a hydrogen atom or C1-6 alkyl, and R9 is C1-6 alkylene; R4, R5, R6 and R7 are the same or different and each is a hydrogen atom or C1-6 alkyl; and X is wherein R10 is a hydrogen atom or C1-6 alkyl; and R11 is optionally substituted phenyl, optionally substituted C1-6 alkyl or a hydrogen atom, or R10 and R11 form, together with the nitrogen atom bonded thereto, an optionally substituted 5- to 7-membered cyclic amino group, or a physiologically acceptable salt thereof.