发明名称 4-(AZACYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS
摘要 4-(azacycloalkyl)benzene-1,3-diol compounds are described corresponding to general formula (I) below:;;Also described, are compositions including the same, processes for preparation thereof and uses thereof in pharmaceutical or cosmetic compositions to treat pigmentary disorders.
申请公布号 US2014187532(A1) 申请公布日期 2014.07.03
申请号 US201414200954 申请日期 2014.03.07
申请人 GALDERMA RESEARCH & DEVELOPMENT 发明人 BOITEAU Jean-Guy;BOUQUET Karine;TALANO Sandrine;MILLOIS BARBUIS Corinne
分类号 C07D211/22;C07D211/26;C07D401/12;C07D205/04;C07D207/08 主分类号 C07D211/22
代理机构 代理人
主权项 1. A method of treating a pigmentary disorder, the method comprising administering an effective amount of at least one compound of general formula (I) to an individual subject in need thereof, wherein the structure of general formula (I) is as follows: in which: R1 represents: a C1-C5 alkyl radical,a C3-C6 cycloalkyl radical,an aryl radical,a substituted aryl radical,an aralkyl radical,a C1-C5 alkoxy radical,an amino radical corresponding to structure (a): in which R2 represents: a hydrogen,a C1-C5 alkyl radical,a C3-C6 cycloalkyl radical, an aryl radical,a substituted aryl radical,a pyridyl radical,an aralkyl radical,a radical corresponding to structure (b): in which p can have the value 1 or 2,a radical corresponding to structure (c): in which R4 represents: a carboxymethyl —COOCH3 or carboxyethyl —COOEt radical,a C1-C3 alkyl radical,a hydrogen,and R5 represents: a substituted or unsubstituted aryl radical,a C3-C6 cycloalkyl radical,a pyridyl,and R3 represents: a hydrogen,a C1-C5 alkyl radical; or R1 may also represent a radical corresponding to formula (d): in which R6 represents: a hydrogen,a C1-C5 alkyl radical,a C3-C6 cycloalkyl radical,an aryl radical,a substituted aryl radical,a pyridyl radical,an aralkyl radical,R7 represents: a hydrogen,a C1-C5 alkyl radical,and R8 represents: a hydrogen,a hydroxyl,an amino radical,a C1-C3 alkoxy radical; Y represents a hydrogen or a fluorine, and m and n can have the value 0, 1 or 2, and also salts of the compounds of formula (I), and isomer and enantiomer forms thereof.
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