EPITOPE PEPTIDES DERIVED FROM VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 AND VACCINES CONTAINING THESE PEPTIDES

摘要

The present invention provides immunogenic peptides comprising the amino acid sequence of SEQ ID NO: 1, 2, 13, 32, and peptides comprising the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted or added, and having cytotoxic T cell inducibility, and also provides drugs for treating or preventing tumors comprising these peptides. The peptides of this invention can be used as vaccines.

主权项

1. A method of treating angiogenesis-mediated disease in a subject comprising administering to the subject a composition comprising a peptide selected from the group consisting of:
(a) an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 1, (b) an isolated peptide having cytotoxic T cell inducibility, wherein the peptide consists of the amino acid sequence of SEQ ID NO: 1, in which 1 or 2 amino acids are substituted, and wherein the second amino acid from the N terminus is leucine or methionine, and the C-terminal amino acid is valine or leucine.