| 摘要 |
The present invention discloses a compound of general formula (I); A is O, S, CH, NH or NR', when O links with Z 3 , Z 1 is N or CR Z1 , Z 2 is CR Z2 , when Z 1 links with O, Z 2 is CH, Z 3 is C-Ar; Ra, Rb, Rc and Rd independently is H, OH, halogen or -Y 1 -R m ; A 1 is NH or CH 2 ; R 1 ' is alkyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl; A 2 is N, O or linking bond; R 1 is hydrogen, or, R 1 linking covalently with R 3 forms C 5 -C 9 saturated or unsaturated hydrocarbon chain substituted by O or N; R 3 is alkyl, cycloalkyl, heterocycloalkyl, alkyl substituted by cycloalky etc; R 4 is alkoxy-CO, alkyl-NHCO, (alkyl) 2 NCO, or formyl substituted by aryl, cycloalkyl, heterocycloalkyl. |
