发明名称 |
RSPO BINDING AGENTS AND USES THEREOF |
摘要 |
The present invention relates to RSPO-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO proteins and modulate &bgr;-catenin activity. The present invention further provides methods of using agents that modulate the activity of RSPO proteins, such as antibodies that specifically bind RSPO1, RSPO2, and/or RSPO3 and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer. |
申请公布号 |
EP2731625(A1) |
申请公布日期 |
2014.05.21 |
申请号 |
EP20120814264 |
申请日期 |
2012.07.13 |
申请人 |
ONCOMED PHARMACEUTICALS, INC. |
发明人 |
GURNEY, AUSTIN, L.;AXELROD, FUMIKO, TAKADA;HOEY, TIMOTHY, CHARLES;CHARTIER-COURTAUD, CECILE |
分类号 |
C07K16/18;A61K38/17;A61K39/395;A61K45/06;A61P35/00;C07K14/71;C07K16/28;C07K16/30;C07K16/46;G01N33/574 |
主分类号 |
C07K16/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|