| 摘要 |
The present invention provides monoclonal antibodies which specifically recognize the shorter A&bgr; peptides obtained after cleavage of the APP protein mediated by γ-secretase, i.e. the A&bgr;-peptide fragments A&bgr;1-37, A&bgr;3-37, A&bgr;3p-37, A&bgr;1-37 and A&bgr;11p-37, and other like fragments ending at the 37th amino acid of APP, hereinafter also referred to as the A&bgr;x-37 peptides. It further provides hybridoma cells producing the monoclonal antibodies as well as methods for producing the antibodies and the hybridoma cells; and an immunoassay for an A&bgr;x-37 peptide by a competitive method or a sandwich method using the antibody of the present invention; and methods for measuring the level of A&bgr;x-37 peptides in a sample, such as a biological sample. |
