发明名称 |
NOVEL PURIFICATION OF ANTIBODIES USING HYDROPHOBIC INTERACTION CHROMATOGRAPHY |
摘要 |
<p>Disclosed herein are compositions and methods for purifying antibody products from a sample matrix. In particular, the present invention relates to compositions and methods for purifying antibody products employing hydrophobic interaction chromatography media. In certain embodiments, the invention provides a method for reducing process-related impurities (e.g., host cell proteins), as well as product-related substances, including molecular weight variants (e.g., aggregates and fragments of the antibody product).</p> |
申请公布号 |
WO2013176754(A9) |
申请公布日期 |
2014.05.01 |
申请号 |
WO2013US31352 |
申请日期 |
2013.03.14 |
申请人 |
ABBVIE INC. |
发明人 |
HERIGSTAD, MATTHEW OMON;RICH, LINDA E.;LU, STEPHEN MING-TEH;RAMASUBRAMANYAN, NATARAJAN |
分类号 |
A61K39/395;C07K1/16;C07K1/18;C07K1/20;C07K1/22;C07K1/34;C07K1/36 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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