DIMERIC BINDING PROTEINS BASED ON MODIFIED UBIQUITINS
摘要
The present invention refers to novel dimeric proteins obtained from modified ubiquitin capable of binding targets with high affinity. The novel dimeric binding proteins comprise a combination of amino acid substitutions and at least one insertion of amino acids in one of the monomers. The invention is further directed to the use of said proteins in medical diagnosis or treatment methods.
申请公布号
EP2721152(A1)
申请公布日期
2014.04.23
申请号
EP20120729509
申请日期
2012.06.15
申请人
SCIL PROTEINS GMBH
发明人
NERKAMP, JOERG;BOSSE-DOENECKE, EVA;STEUERNAGEL, ARND;FIEDLER, ULRIKE;FIEDLER, MARKUS