发明名称 |
Method for producing pharmaceutical drug particles of small particle size |
摘要 |
Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers. |
申请公布号 |
US8697131(B2) |
申请公布日期 |
2014.04.15 |
申请号 |
US201013138389 |
申请日期 |
2010.02.11 |
申请人 |
TUERELI AKIF EMRE;PENTH BERND;LANGGUTH PETER;BAUMSTUEMMLER BERND;INSTILLO GMBH |
发明人 |
TUERELI AKIF EMRE;PENTH BERND;LANGGUTH PETER;BAUMSTUEMMLER BERND |
分类号 |
A61K9/14;A61K9/127;B01J13/02 |
主分类号 |
A61K9/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|