发明名称 |
MODULATION OF RNA ACTIVITY AND VASCULAR PERMEABILITY |
摘要 |
The present invention provides oligonucleotides that inhibit the binding of miR-27a to VE-cadherin mRNA, particularly in the form of blockmirs. The invention also provides compositions comprising such oligonucleotides and methods of use of such oligonucleotides to modulate the activity of VE-cadherin, inhibit or reduce vascular permeability, treat or prevent a vascular permeability-associated disease or condition, inhibit tumour growth, treat ischaemic injury, enhance recovery from ischaemic injury, treat surgical wounds and/or promotes post-operative recovery, and promote or induce angiogenesis. |
申请公布号 |
CA2886745(A1) |
申请公布日期 |
2014.04.10 |
申请号 |
CA20132886745 |
申请日期 |
2013.10.02 |
申请人 |
CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY;MIRRX THERAPEUTICS A/S;UNIVERSITY OF SYDNEY |
发明人 |
GAMBLE, JENNIFER;VADAS, MATHEW;MOLLER, THORLEIF |
分类号 |
C12N15/113;A61K31/7088;A61K48/00;A61P7/10;A61P9/00;A61P35/00 |
主分类号 |
C12N15/113 |
代理机构 |
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地址 |
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