| 摘要 |
1,159,970. The antibiotic steffisburgensimycin. UPJOHN CO. 12 Dec., 1966 [29 Dec., 1965], No. 55535/66. Heading C2A. The invention relates to an antibiotic steffisburgensimycin, which is active against gram-positive bacteria, tumours and fungi; forms yellow/light-orange crystals, yellow in aqueous solution and red-violet in alkaline solution; is soluble in methanol, ethanol, isopropanol, methylene chloride, chloroform, ethylene dichloride, acetone and methyl ethyl ketone; has the elementary analysis C=58À31%, H=5À52%, O=35À89%, formula C 28 H 30 O 13 ; optical rotation [α]<SP>25</SP> D = +85‹ (methanol); ultraviolet absorption spectrum (0À01 N.KOH in methanol) maxima at 227 mÁ,α=51À93; 263 mÁ, a=42À86; 353 mÁ, a=7À20; 5À28 mÁ, a= 19À44; infra-red spectrum as in Fig. 1 and characteristic paper chromatographic pattern as in Fig. 2 (not shown). The antibiotic is produced by cultivating Streptomyces steffisburgensis var. steffisburgensis especially NRRL 3193 in an aqueous nutrient medium. The antibiotic is recovered from a clarified broth by extraction with a water-immiscible solvent, e.g. methylene chloride, followed by recrystallization of the crude from a solvent such as isopropanol. Purification may be by liquid-liquid distribution in a Craig apparatus. Steffisburgensimycin alone or in admixture with other antibacterials may be used as a general disinfectant, e.g. in washing utensils, in papermill operations and in the storage of petroleum products. It may be used in the treatment of tuberculosis in animals and also as a feed supplement.
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