发明名称 |
STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA |
摘要 |
<p>The present invention describes a flexible basestacking monomer that can be incorporated into an oligonucleotide or oligonucleotide analogue, as well as triplex forming oligonucleotides comprising the flexible basestacking monomer. Triplex forming oligonucleotides of the invention are capable of binding sequence specifically to doublestranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids.</p> |
申请公布号 |
SI1888748(T1) |
申请公布日期 |
2014.02.28 |
申请号 |
SI20060031698T |
申请日期 |
2006.05.24 |
申请人 |
TINA HOLDING APS |
发明人 |
FILICHEV VYACHELSAV V.;PEDERSEN ERIK BJERREGAARD |
分类号 |
C12N15/11 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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