CAMPTOTHECIN COMPOUND CONTAINING STABLE 7-MEMBERED LACTONE RING, PREPARATION METHOD AND USE

摘要

Provided are a camptothecin compound containing 7-membered lactone ring, as shown in general formula I, and pharmaceutically acceptable salt thereof, as well as the preparation method and use thereof. In general formula I, R 1 is H, a C1ˆ¼C3 alkyl, acetyl or propionyl; R 2 is H, a C1ˆ¼C6 alkyl, a C3~C6 cycloalkyl, piperidyl; or a C1ˆ¼C6 alkyl substituted by an amino; R 3 is H, a C1ˆ¼C3 alkyl, or a C1ˆ¼C6 alkyl substituted by an amino; R 4 is H, a hydroxyl, or a C1ˆ¼C6 alkoxy; R 5 is H, or a C1ˆ¼C6 alkoxyl; or R 4 and R 5 are linked to each other to form -OCH 2 O- or -OCH 2 CH 2 O-. The compound has good anti-tumor activity, and can be clinically used via oral administration, intravenous injection, and intramuscular injection, among others.