发明名称 |
An insulin conjugate using an immunoglobulin fragment |
摘要 |
The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment. |
申请公布号 |
AU2011233800(B2) |
申请公布日期 |
2014.02.06 |
申请号 |
AU20110233800 |
申请日期 |
2011.04.04 |
申请人 |
HANMI SCIENCE CO., LTD. |
发明人 |
SONG, DAE HAE;SHIN, JAE HEE;PARK, YOUNG JIN;IM, DAE SEONG;BAE, SUNG MIN;KWON, SE CHANG |
分类号 |
A61K38/28;A61K9/20;A61K47/34;A61K47/40 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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