发明名称 Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses
摘要 Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
申请公布号 US8642596(B2) 申请公布日期 2014.02.04
申请号 US20050791926 申请日期 2005.12.06
申请人 DENG YIJUN;NITZ THEODORE J.;BAILEY THOMAS R.;ZHANG YUANMING;LAQUERRE SYLVIE;SIGA TECHNOLOGIES, INC. 发明人 DENG YIJUN;NITZ THEODORE J.;BAILEY THOMAS R.;ZHANG YUANMING;LAQUERRE SYLVIE
分类号 A61K31/175;A61K31/5375;C07C281/06;C07D241/04;C07D265/30 主分类号 A61K31/175
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