| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an oral disintegrating tablet comprising mitiglinide calcium hydrate, which shows reduced bitter taste and rapid disintegrating properties in an oral cavity, and shows rapid elution properties in a digestive tract. <P>SOLUTION: This oral disintegrating tablet includes bitterness-masking particles formed by granulating a mixture of mitiglinide calcium hydrate as a bitter active ingredient and crystalline cellulose by a high-speed agitated granulation method while spraying at least one type of masking agent selected from the group consisting of stomach-soluble polymer, water-insoluble cellulose ether, and water-insoluble acrylic polymer. The average particle size of the particles is 60 to 150 μm. <P>COPYRIGHT: (C)2013,JPO&INPIT |
