MALEIMIDE-FURANYL COMPOUNDS THAT CAN BE USED IN A GENERAL METHOD FOR PREPARING MALEIMIDE-OLIGONUCLEOTIDE DERIVATIVES

摘要

The compounds of formula (I) substantially in exo form or salts thereof, wherein: X is a biradical selected from -(CH2)n-*, -(CH2CH2O)nCH2CH2-*, methylcyclohexyl and methylphenyl; n is an integer ranging between 1 and 30; Y is a radical selected from -COOH, a substituted phosphoramidite radical and N-hydroxysuccinimide ester (or other active ester) of carboxylic acid; and * represents the place through which X binds to Y, are useful in a general process for solid-phase preparation of maleimide-oligonucleotide derivatives.